Autoreactivity in Human IgG+ Memory B Cells
نویسندگان
چکیده
منابع مشابه
Autoreactivity in human IgG+ memory B cells.
More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen-experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently fou...
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ژورنال
عنوان ژورنال: Immunity
سال: 2007
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2007.01.009